![]() ![]() The animal model is not only available for human Taenia spp but can also be applied to other taeniid cestodes of economic importance or in veterinary parasitology. Non-obese diabetic scid (NOD-scid) mice are expected to be a satisfactory animal model and to have advantages for analysis by several view points of developmental biology with gene expression throughout development, antigenic homology of cyst fluid of these three species, evaluation of drug efficacy or metacestocidal drug designs, confirmation of unknown taeniid gravid segments for identification based on the morphology and DNA analysis of metacestodes. Despite their suitability for numerous applications, NOD scid mice exhibit some characteristics that can be disadvantageous for certain research purposes. In this brief review, we introduce experimental animal model for these three species in order to obtain fully developed metacestode stage in severe combined immunodeficiency (scid) mice. The immunologic profile of the NOD scid mouse renders it useful for biomedical research in oncology, immunology, hematology, HIV pathology, and other fields. It is developed and marketed by Jackson Laboratory. That model is even tighter, and affects the innate immune system as well. pdfImage4.pdf Human epicardium-derived cells (hEPDCs) transplanted in the NOD-SCID mouse heart after myocardial infarction (MI) are known to improve. The NSG mouse (NOD Scid gamma mouse) is the most severely immunocompromised mouse model available for research use. There's also a NOD/SCID/gamma mouse, which is a NOD/SCID mouse with the IL-2 common gamma chain receptor knockout. Also, impaired ability to make NK cells, which SCID mice make just fine. As these human taeniid cestodes obligatory require domestic animals such as swine, cattle and swine as the major intermediate host animals respectively, it is not easy to analyze the basic research in these domestic animals. When they crossed SCID mice onto the NOD background, they got less leakiness. Engraftment levels of human cells in the NOD scid were reported to be 5-10 fold higher than in the parental SCID mouse. Neurocysticercosis (NCC) in humans is now recognized as the major cause of neurologic disease in the world. Crossing the NOD and SCID mice produced the NOD scid, defective in both T and B cell functions, as well as having an increased deficiency in macrophage function, complement-dependent hemolytic activity, and NK activity. solium is the most serious with medical and economic importance. asiatica) which require humans as the definitive host are still not rare in developing countries. hCNS-SCns transplanted mice demonstrated significantly improved locomotor recovery compared to vehicle controls using open field locomotor testing and CatWalk gait analysis. The major three species of human taeniid cestodes, Taenia solium, T. US9018441B2 - Hairless NOD scid mouse - Google Patents Hairless, immunodeficient mice on a non-obese diabetic (NOD) background and methods for their production are disclosed herein. and Findings: hCNS-SCns were transplanted into immunodeficient NOD-scid mice 30 days post spinal cord contusion injury. ![]()
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